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Using immunohistochemical and radioimmunohistochemical techniques, we have investigated the distribution of calcitonin gene-related peptide (CGRP) in the vagus nerve of the rat. The number of CGRP-immunoreactive fibers in the nodose ganglion was much greater than that of other peptide-containing fibers. CGRP-immunoreactive neurons were localized in the nodose and jugular ganglia. CGRP-immunoreactive nerve fibers were distributed in all parts of the digestive tract, especially the esophagus, stomach, and small intestine. They were also abundant in the larynx and upper respiratory tract. CGRP-immunoreactive fibers were particularly numerous in the adventitia of the aorta, pulmonary trunk, pulmonary artery, portal vein, and mesenteric vein. In the paravertebral and pelvic ganglia, many nerve fibers containing CGRP were present. In the subepicardium, many CGRP-immunoreactive fibers were seen. CGRP-immunoreactive nerve fibers in the skin were relatively scarce. In the nervous system, a few nerve cells immunoreactive for CGRP were seen in the central and peripheral nervous systems. These results indicate that CGRP-containing vagal neurons are widely distributed throughout the body. They are considered to be involved in vagal-mediated cardiovascular regulation, motor activity of the digestive tract, sensory transmission of the afferent fiber, and pain transmission in the skin.High-tech spin
Discovery Schools to China: ‘We’ve got the magic touch’
Oscar Torres, pictured, will set his sights on China, as he heads a new school based in the city of Guangzhou in southern China. – Photo: Discovery Communications
New Discovery-sponsored school to be set up in China
New Discovery Schools is to set up a school in China, an 0b46394aab